What is Sildenafil?

Sildenafil is a drug that is mainly used in the treatment of erectile dysfunction (ED), and also pulmonary arterial hypertension (PAH). It was initially formulated by scientists in UK and was later on marketed by Pfizer, a leading pharmaceutical firm. The main purpose is to cause vasodilation of blood vessels and to bring more blood to certain regions of the body.

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Sildenafil is used for erectile dysfunction whereby it enables men to get and sustain an erection during sexual activity through increasing the effectiveness of the natural erectile process. It achieves this by preventing the action of a substance known as phosphodiesterase type 5 (PDE5) that tends to limit blood flow to the penis.

When taken for treating pulmonary arterial hypertension, sildenafil helps to undo the constriction of the blood vessels in the lungs hence enabling smooth flow of blood and at the same time reducing the work load on the heart.

The drug comes in the form of a small blue pill and is usually swallowed, it begins to act within 30 to 60 minutes. Possible side effects are headache, redness of the face, and stomach upset. Sildenafil has been a revolutionary treatment for numerous patients but it is advisable to take it with the prescription of a doctor to prevent adverse reactions and complications.

Buy Erectile Dysfunction pill online in USA

Therefore, prospective consumers of sildenafil who intends to purchase it online in the USA should be very careful and legal. A genuine online drug store, Rejics Pharma has stock a sildenafil on sale. They feature a safe website that shows detailed information on the products, proper dosage, and customer service ought to customers have any issues.

Before making the actual purchase, ensure that Rejics Pharma Company is authorized to do business in your state and that it has met all the legal demands on the internet sale of pharmaceuticals. Make sure that they demand a prescription when administering sildenafil to their customers since this helps in checking on the safety of their customers.

When ordering, give correct health details to avoid taking the wrong ed drugs or drugs you might be allergic to. Do not buy the sildenafil online without a prescription or at cheap prices as most of them are fake or of very poor quality. Rejics Pharma focuses on customer’s protection due to which it is one of the best places to buy sildenafil in the USA.

What is Sildenafil used for?

Sildenafil is a PDE5 inhibitor with main indications for erectile dysfunction treatment and pulmonary arterial hypertension.

In the case of erectile dysfunction which is a common sexual dysfunction in men, a similar treatment that helped men was Sildenafil. This one functions in a way that it enhances blood supply to the penis at the point in time where the man is sexually aroused making it easier for him to get an erection. This has been revolutional for the men with erectile dysfunction as it has boosted their sexual well-being and life in general.

Sildenafil in treating PAH, acts by producing vasodilation of the blood vessels particularly in the lung which widens the diameter of the vessels. These result in lowering of the pulmonary blood pressure that facilitates the ability of the heart to pump blood in a proper manner; thus the signs and symptoms of dyspnoea, lightheadedness and fatigue. This increase in pulmonary blood flow enhances the patients’ functional capabilities and exercise capacity and consequently their overall quality of life.

Sildenafil is a ed tablet, which is intended to be ingested, although the immediate use of the drug should be discussed with a medical practitioner. This is useful in preventing combination toxicities and interaction with other drugs that the patient may be taking as well as the side effects of headache, flushing and stomach upsets. For appropriate recommendation on usage, it is suggested that the client seek advice from a doctor.

Working of Sildenafil

As for Sildenafil, its mechanism of action involves blocking of phosphodiesterase type 5 (PDE5) which is an enzyme. Under normal physiological conditions, PDE5 hydrolyzes a molecule cGMP, which is important in penile erection. This molecule is important in causing relaxation of smooth muscles in the body and vasodilation of the blood vessels.

Sildenafil by its action suppresses the PDE5 that leads to the non-degradation of cGMP and thus an erection is achieved. Thus, cGMP elevates and the smooth muscle relaxes and blood vessels dilates for a longer time.

For erectile dysfunction, it implies that when a man is sexually stimulated, the inflow of blood in the penis gives and sustains an erection.

In the case of pulmonary arterial hypertension treatment, the nitric oxide causes the blood vessels in the lungs to relax and dilate, thus reducing the pulmonary blood pressure thereby easing the task of the heart to pump blood that is rich in oxygen through the lungs.

Sildenafil is available in tablets, and usually, the effect occurs 30 minutes up to 1 hour after the intake, which makes it perfect for those diseases.

Benefits of Sildenafil

Sildenafil is rather beneficial for patients suffering from erectile dysfunction as well as pulmonary arterial hypertension.

Sildenafil for people with pill for ed means a dependable method of attaining and sustaining an erection, improving both the physical aspect of sex and, thus, the character of a man’s life. This improvement in sexual health can also extend the personal well-being and relational mindset and functions.

For PAH, sildenafil works by carrying out a smooth relaxation of the blood vessels in the lungs and thus lowering pulmonary blood pressure. Such relief of pressure also means that the heart can pump a greater amount of blood and results in better exercise tolerance and decrease in features such as shortness of breath and general fatigue.

In conclusion, sildenafil is a highly useful pharmaceutical preparation that positively affects the physical condition of a human body and improves the quality of the person’s life. For this reason, the advantage of using the cosmetic products goes beyond the improvement of the physical status of the affected person, it also has the effect of improving the mental and the emotional health.

Dosages of Sildenafil

Sildenafil comes in different strengths for the individualised requirement with two principal indications; erectile dysfunction and pulmonary arterial hypertension.

In treating, sildenafil potency comes in three forms of 25mg, 50mg and 100mg tablets. The initial dose suggested for most of the males is 50 mg of the drug, which is to be taken an hour before sexual propositions. Still, according to the effectiveness and tolerance, the dose can be as low as 25 mg and as high as 100 mg. Before ordering sildenafil, it is necessary to state that it cannot be used more than once a day.

For patients with pulmonary arterial hypertension the amount given is 20mg thrice daily and with at least 4 to 6hrs between doses. This regimen assist in managing symptoms and exercising capacities among those with this illness.

The metabolism of a ed drug and its effects may vary for each patient and thus the dosage should be adjusted according to response and tolerance; thus it is essential to adhere to the prescription given by a medical practitioner. Use of sildenafil under the doctor’s prescription eliminates chances of adverse effects due to the use of the drug or with other drugs.

Side effects of Sildenafil

Sildenafil is used to treat erectile dysfunction and pulmonary hypertension however, its use has side effects. Typically, these are moderate and rare in severity however, some may produce severe symptoms.

The side effects include headache, flushing and indigestion. These are observed because sildenafil enhances blood circulation while at the same time dilating the blood vessels. Nasal congestion is another symptom that some people might develop dizziness; and vision problems – a bluish tinge to vision / photosensitivity.

Rare but more severe side effects are sudden hearing loss or vision loss which should be reported to the doctor as soon as possible. Occasionally, sildenafil may lead to what is known as priapism, a painful erection lasting over four hours, is a medical emergency.

Rhabdomyolysis leading to muscle pain, backache, and allergic reactions such as rashes, itchy skin, and swelling could be other side effects of this drug.

Drug Interactions

The list of drugs and combinations that may cause an interaction with sildenafil is as follows: However, it should not be used together with nitrates which is used for chest pain as it may cause a wide drop in blood pressure.

Some of the other drugs that one has to be careful with when taking Sildenafil include antihypertensive drugs, alpha-blockers, and some of the antifungal/antibiotic classes of drugs since will enhance or exacerbate effects of Sildenafil.

Besides, it can have an effect on other medicines intended for the treatment of pulmonary arterial hypertension. Thus, one must always report any medications and supplements they take to their doctors to prevent adverse side effects and proper use of sildenafil.

Disease Interactions

Sildenafil has been known to interconnect with different diseases, this makes it very risky to use. In patients with heart problems, especially having severe forms of heart diseases or recent myocardial infarction, it should be used carefully as it influences blood circulation and blood pressure. Patients with liver or kidney disease can have change in their body metabolism rates hence may need different dosages of the same medication.

However, these medications can worsen some pres-M conditions including low blood pressure, severe dehydration and some types of eye problems, including retinitis pigmentosa. Similar to the risk of stroke, people who have a history of peptic ulcer and other gastrointestinal bleeding should be careful. These disease interactions should be handled safely and so anyone developing these diseases should consult a health care provider before taking sildenafil.

Food Interaction

It has been established that sildenafil can be influenced by foods some of which are detailed below. The fat content of a meal also affects sildenafil because a high fat meal will slow down the rate at which the substance is absorbed hence, reducing the effectiveness of the Viagra as well as the time it takes before it starts to work.

Grapefruit and its juice can increase the levels of sildenafil in your blood and this in turn may lead to side effects of the drug. Erectile dysfunction medication sildenafil should be taken without food or after the light meal for the best effect.

It is equally wise to abstain from taking alcohol in large quantities, because it causes some side effects such as dizziness and low blood pressure. Sildenafil should be taken strictly according to the decision of your health care provider, including the diet.

Precautions and Warnings

Before using sildenafil, it’s essential to consider several precautions and warnings. Inform your healthcare provider about any medical conditions, especially heart problems, low blood pressure, or liver or kidney disease.

Avoid combining sildenafil with nitrates, as this can cause a dangerous drop in blood pressure. If you experience sudden vision or hearing loss while using sildenafil, seek immediate medical attention.

Use caution if you have a history of priapism or certain eye disorders.Pregnant or breastfeeding women should consult their doctor before using sildenafil.


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